Clinical Trial Center, Beijing Hospital, National Center of Gerontology; Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, People's Republic of China. Clinical Pharmacology and Exploratory Development, Astellas Pharma Inc., Tokyo, Japan. Analysis & Pharmacokinetics Research Labs., Astellas Pharma Inc., Ibaraki, Japan. Development Medical Department, Astellas (China) Investment Co., Ltd, Beijing, People's Republic of China. Data Science Development, Astellas Pharma US, Inc., Northbrook, IL, USA. Development Division Biostatistics and Statistical Programming, Astellas (China) Investment Co., Ltd, Beijing, People's Republic of China. Biostatistics Group, Japan-Asia Data Science, Development, Astellas Pharma Inc, Tokyo, Japan.